OXA (17-33) (TFA)
OXA (17-33) TFA is a potent and selective orexin-1 receptor (OX1) agonist. OXA (17-33) TFA shows a ∼23-fold selectivity for the OX1 (EC50=8.29 nM) over OX2 (187 nM) [1].
Product Specifications
Product Name Alternative
Orexin A (17-33) (human, mouse, rat, bovine) (TFA)
UNSPSC
12352209
Target
Orexin Receptor (OX Receptor)
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/oxa-17-33-tfa.html
Solubility
10 mM in DMSO
Smiles
OC(C(F)(F)F)=O.OC(C=C1)=CC=C1C[C@H](N)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC2=CN=CN2)C(NCC(N[C@@H](C)C(NCC(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](C)C(N[C@@H](C)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N[C@H](C(N)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)CC3=CN=CN3)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C81H126F3N23O24
Molecular Weight
1863.00
References & Citations
[1]German NA, et al. Truncated Orexin Peptides: Structure-Activity Relationship Studies. ACS Med Chem Lett. 2013;4 (12) :1224-1227.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
OX1 Receptor; OX2 Receptor
Frequently Asked Questions
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