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Taurocholic acid (sodium)

Taurocholic acid sodium (Sodium taurocholate) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid sodium has immunoregulation effect[1].

Product Specifications

CAS Number

[145-42-6]

Product Name Alternative

Sodium taurocholate; N-Choloyltaurine (sodium)

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; VEGFR

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/taurocholic-acid-sodium.html

Purity

99.82

Solubility

DMSO : ≥ 100 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

C[C@H](CCC(NCCS(=O)(O[Na])=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C

Molecular Formula

C26H44NNaO7S

Molecular Weight

537.68

Precautions

H302, H315, H319, H335

References & Citations

[1]Caiyun Wang, et al. Effects of taurocholic acid on immunoregulation in mice. Int Immunopharmacol. 2013 Feb;15 (2) :217-22.|[2]Xun Z, et al. Taurocholic acid inhibits the response to interferon-α therapy in patients with HBeAg-positive chronic hepatitis B by impairing CD8+ T and NK cell function. Cell Mol Immunol. 2021 Feb;18 (2) :461-471. |[3]Glaser S, et al. Taurocholic acid prevents biliary damage induced by hepatic artery ligation in cholestatic rats. Dig Liver Dis. 2010 Oct;42 (10) :709-17.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Natural Products

Clinical Information

Phase 2

Isoform

Human Endogenous Metabolite; Microbial Metabolite

Citation 01

Adv Healthc Mater. 2024 Dec 4:e2402773.|FASEB J. 2022 May;36 (5) :e22305.|Int J Mol Sci. 2025 Feb 22;26 (5) :1899.|Microbiome. 2025 Jun 18;13 (1) :145.|Nat Commun. 2025 Aug 30;16 (1) :8124.|Proc Natl Acad Sci U S A. 2025 Dec 2;122 (48) :e2524436122.|Research Square Preprint. 2024 Feb 13.|Sci Rep. 2024 Oct 31;14 (1) :26216.|Adv Sci (Weinh) . 2025 Feb 3:e2411719.|Antiviral Res. 2019 Sep:169:104544.|Biochim Biophys Acta Mol Cell Biol Lipids. 2025 Oct 3;1871 (1) :159692.|Biomedicines. 2025 Apr 4;13 (4) :874.|Cell Death Discov. 2025 Jul 23;11 (1) :338.|Food Funct. 2024 Apr 11.|Food Funct. 2024 Sep 30;15 (19) :9916-9927.|Int Immunopharmacol. 2024 Dec 10:145:113739.|J Enzyme Inhib Med Chem. 2025 Dec;40 (1) :2501743.|J Pharm Biomed Anal. 2025 Jul 15:259:116760.|J Transl Med. 2024 Dec 20;22 (1) :1124.|Nature. 2025 Jul;643 (8070) :192-200.|Placenta. 2024 Mar 25:148:20-30.|Plant Commun. 2025 Jan 13;6 (1) :101181.|Poult Sci. 2025 Jun 25;104 (9) :105489.|Research (Wash D C) . 2022 Nov 2:2022:9784081.|Research Square Print. 2022 Aug.|Science. 2024 Mar 22;383 (6689) :eadj4591.|Biomolecules. 2022 Jul 31;12 (8) :1063.|RSC Adv. 2018 8:8469-8483.|SSRN. 2022 Jan 26.

Available Sizes

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