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Desmethoxyyangonin (Standard)

Desmethoxyyangonin (Standard) is one of the six major kavalactones found in the Piper methysticum (kava) plant. Desmethoxyyangonin (Standard) is a selective inhibitor of monoamine oxidase-B (MAO-B) (IC50: 0.123 µM) . Desmethoxyyangonin (Standard) exerts anti-inflammatory effects by inhibiting Jak2/STAT3 and IKK signaling pathways. Desmethoxyyangonin (Standard) induces CYP3A23 expression and leads to skeletal muscle relaxation[1][2][3][4].

Product Specifications

CAS Number

15345-89-8

Product Name Alternative

Demethoxyyangonin (Standard) ; 5,6-Dehydrokavain (Standard)

UNSPSC

12352005

Target

Cytochrome P450; IKK; JAK; Monoamine Oxidase; NO Synthase; Reference Standards; STAT

Type

Reference Standards

Related Pathways

Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/desmethoxyyangonin-standard.html

Smiles

O=C1C=C(OC)C=C(/C=C/C2=CC=CC=C2)O1

Molecular Formula

C14H12O3

Molecular Weight

228.24

References & Citations

[1]Chaurasiya ND, et al. Interactions of Desmethoxyyangonin, a Secondary Metabolite from Renealmia alpinia, with Human Monoamine Oxidase-A and Oxidase-B. Evid Based Complement Alternat Med. 2017;2017:4018724.|[2]Chou TW, et al. A plant kavalactone desmethoxyyangonin prevents inflammation and fulminant hepatitis in mice. PLoS One. 2013 Oct 15;8 (10) :e77626.|[3]Baum SS, et al. Effect of kava extract and individual kavapyrones on neurotransmitter levels in the nucleus accumbens of rats. Prog Neuropsychopharmacol Biol Psychiatry. 1998 Oct;22 (7) :1105-20.|[4]Ma Y, et al. Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23. Drug Metab Dispos. 2004 Nov;32 (11) :1317-24.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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