Retinoic acid (GMP)

Retinoic acid (Vitamin A acid) (GMP) is Retinoic acid (HY-14649) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Retinoic acid is an agonist of RAR nuclear receptors[1][2][3][4][5][6].

Product Specifications

CAS Number

[302-79-4]

Product Name Alternative

Vitamin A acid (GMP) ; all-trans-Retinoic acid (GMP) ; ATRA (GMP)

UNSPSC

12352211

Hazard Statement

H302, H315, H360, H410

Target

Autophagy; Endogenous Metabolite; PPAR; RAR/RXR

Type

GMP Small Molecules

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/retinoic-acid-gmp.html

Purity

99.9

Solubility

DMSO : 50 mg/mL (ultrasonic; warming)

Smiles

CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/C(O)=O)=C(C)CCC1

Molecular Formula

C20H28O2

Molecular Weight

300.44

Precautions

H302, H315, H360, H410

References & Citations

[1]Rohwedel J, et al. Induction of cellular differentiation by retinoic acid in vitro. Cells Tissues Organs. 1999;165 (3-4) :190-202.|[2]Sherman MI, et al. Differentiation of early mouse embryonic and teratocarcinoma cells in vitro: plasminogen activator production. Cancer Res.|[3]Kelley MW, et al. Retinoic acid promotes differentiation of photoreceptors in vitro. Development. 1994 Aug;120 (8) :2091-102.|[4]Påhlman S, et al. Retinoic acid-induced differentiation of cultured human neuroblastoma cells: a comparison with phorbolester-induced differentiation. Cell Differ. 1984 Jun;14 (2) :135-44.|[5]Sidell N. Retinoic acid-induced growth inhibition and morphologic differentiation of human neuroblastoma cells in vitro. J Natl Cancer Inst. 1982 Apr;68 (4) :589-96.|[6]Hyatt GA, et al. Retinoic acid alters photoreceptor development in vivo. Proc Natl Acad Sci U S A. 1996 Nov 12;93 (23) :13298-303.