SJ6145
SJ6145 is a potent ligand for KLHDC2SBD, with the Kd of 16.9 μM in SPR test, IC50 value of 42 μM in inhibiting KLHDC2SBD binding to a di-Gly degron peptide test[1].
Product Specifications
CAS Number
[1010913-79-7]
UNSPSC
12352211
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sj6145.html
Smiles
O=C(CNC(CC1=CSC(C2=C(C=CC=C2)F)=N1)=O)O
Molecular Formula
C13H11FN2O3S
Molecular Weight
294.30
References & Citations
[1]Daniel C Scott, et al. Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2. Nat Commun. 2024 Oct 12;15 (1) :8829. doi: 10.1038/s41467-024-52966-3.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KLHDC2
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