Histone H3K9me3 (1-15) (TFA)

Histone H3K9me3 (1-15) (H3(1-15)K9me3) TFA is used as substrate. Histone H3K9me3 is a histone posttranslational modification (PTM) that has emerged as hallmark of pericentromeric heterochromatin[1][2].

O=C([C@@H](N)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(O)=O)C)=O)CCCCN)=O)=O)=O)[C@@H](C)O)=O)CO)=O)CCCC[N+](C)(C)C)=O)CCCNC(N)=N)=O)C)=O)[C@@H](C)O)=O)CCC(N)=O)=O)CCCCN)=O)[C@@H](C)O)=O)CCCNC(N)=N.O=C(C(F)(F)F)O.[x]

[1]Kerstin Mosch, et al. HP1 recruits activity-dependent neuroprotective protein to H3K9me3 marked pericentromeric heterochromatin for silencing of major satellite repeats. PLoS One. 2011 Jan 18;6(1):e15894.|[2]Esther C Y Woon, et al. Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases. Angew Chem Int Ed Engl. 2012 Feb 13;51(7):1631-4.