APX2039
APX2039 is an orally active and potent inhibitor of the fungal Gwt1 enzyme. APX2039 has extremely potent anticryptococcal activity against C. neoformans and C. gattii. APX2039 blocks the localization of GPI (glycosylphosphatidyl inositol) -anchored cell wall mannoproteins. APX2039 can be used for Cryptococcal meningitis (CM) research[1][2].
Product Specifications
CAS Number
2342606-49-7
UNSPSC
12352005
Target
Fungal
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/apx2039.html
Purity
98.44
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=NC=CC=C1C2=CC(CC3=CC=C(C=C3)OC4=NC(F)=CC=C4)=NO2
Molecular Formula
C20H15FN4O2
Molecular Weight
362.36
References & Citations
[1]Karen J Shaw, et al. 168. Efficacy of the Novel gwt1 Inhibitor APX2039 in a Rabbit Model of cryptococcus Meningitis. Open Forum Infect Dis. 2020 Dec 31.|[2]Yu CH, et al. Gene Expression of Diverse Cryptococcus Isolates during Infection of the Human Central Nervous System. mBio. 2021 Dec 21;12 (6) :e0231321.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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