EGFR-IN-108
EGFR-IN-108 (Compound 12) is a selective and covalent EGFR inhibitor (pIC50: 9.4) [1].
Product Specifications
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-108.html
Solubility
10 mM in DMSO
Smiles
COC1=CC2=NC=NC(NC3=C(C(Cl)=CC=C3)F)=C2C=C1OC4=CC=NC(/C=C/CN(C)C)=C4
Molecular Formula
C25H23ClFN5O2
Molecular Weight
479.93
References & Citations
[1]Nils Pemberton, et al. Vinylpyridine as a Tunable Covalent Warhead Targeting C797 in EGFR.ACS Med. Chem. Lett. 2024
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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