Dihydrostreptomycin (sulfate)

Dihydrostreptomycin sulfate (DHSM sulfate) is the sulfate salt form of Dihydrostreptomycin (HY-B1241A) . Dihydrostreptomycin sulfate is an aminoglycoside antibiotic with antibacterial effect against Gram-negative bacteria. Dihydrostreptomycin sulfate exhibits ototoxicity that causes irreversible damage in inner ear hair cells, leading to hearing loss[1].

Product Specifications

CAS Number

[5490-27-7]

Product Name Alternative

DHSM (sulfate)

UNSPSC

12352005

Hazard Statement

H302, H361

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

Neuroscience-Neuromodulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Dihydrostreptomycin-sulfate.html

Purity

99.68

Solubility

DMSO : 5.83 mg/mL (ultrasonic) |H2O : 250 mg/mL (ultrasonic)

Smiles

O[C@@H]1[C@@H](O)[C@@](O[C@@H]2O[C@@H](C)[C@](O)(CO)[C@H]2O[C@@]3([H])[C@@H](NC)[C@H](O)[C@@H](O)[C@H](CO)O3)([H])[C@@H](NC(N)=N)[C@H](O)[C@H]1NC(N)=N.[1.5H2SO4]

Molecular Formula

C21H41N7O12.3/2H2SO4

Molecular Weight

730.71

Precautions

H302, H361

References & Citations

[1]Marcotti W, et al. The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channels. J Physiol. 2005 Sep 1;567 (Pt 2) :505-21.|[2]Yamashita H, et al., Cell proliferation in spiral ligament of mouse cochlea damaged by dihydrostreptomycin sulfate. Acta Otolaryngol. 1999;119 (3) :322-5.