15 (S) -HETRE

15 (S) -HETRE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-γ-linolenic acid. It is an inhibitor of 5-LO in human PMNL with an IC50 value of 4.6 μM. In RBL cells, 15 (S) -HETrE inhibits 5-LO, but is about 1/20 as potent as 15 (S) -HpETE.

Product Specifications

CAS Number

[92693-02-2]

UNSPSC

12352211

Target

Lipoxygenase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/15-s-hetre.html

Concentration

310.10 μM * 1 mL in Ethanol

Purity

99.0

Smiles

CCCCC[C@H](/C=C/C=C\C/C=C\CCCCCCC(O)=O)O

Molecular Formula

C20H34O3

Molecular Weight

322.48

References & Citations

[1]Haviv, et al. Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues. J. Med. Chem. 30 (2), 254-263 (1987) .