15 (S) -HETRE
15 (S) -HETRE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-γ-linolenic acid. It is an inhibitor of 5-LO in human PMNL with an IC50 value of 4.6 μM. In RBL cells, 15 (S) -HETrE inhibits 5-LO, but is about 1/20 as potent as 15 (S) -HpETE.
Product Specifications
CAS Number
92693-02-2
UNSPSC
12352211
Target
Lipoxygenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/15-s-hetre.html
Concentration
310.10 μM * 1 mL in Ethanol
Purity
99.0
Smiles
CCCCC[C@H](/C=C/C=C\C/C=C\CCCCCCC(O)=O)O
Molecular Formula
C20H34O3
Molecular Weight
322.48
References & Citations
[1]Haviv, et al. Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues. J. Med. Chem. 30 (2), 254-263 (1987) .
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, protect from light, 2 years
Scientific Category
Natural Products
Clinical Information
No Development Reported
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