Tyrosinase, Mushroom

Tyrosinase (EC 1.14.18.1) (Polyphenol oxidase) is a rate-limiting enzyme that controls the production of melanin. Tyrosinase is mainly found in melanosomes synthesized by skin melanocytes. Tyrosinase can be used in research on Parkinson's disease, melanoma and pigmentation[1][2][3].

Product Specifications

CAS Number

[9002-10-2]

Product Name Alternative

Polyphenol oxidase

UNSPSC

12352204

Hazard Statement

H334

Target

Tyrosinase

Type

Enzyme

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Endocrinology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tyrosinase.html

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

[Tyrosinase,Mushroom]

Precautions

H334

References & Citations

[1]Sánchez-Ferrer A, et al. Tyrosinase: a comprehensive review of its mechanism. Biochim Biophys Acta. 1995 Feb 22;1247 (1) :1-11. |[2]Peng LH, et al. Inhibitory effects of salidroside and paeonol on tyrosinase activity and melanin synthesis in mouse B16F10 melanoma cells and ultraviolet B-induced pigmentation in guinea pig skin. Phytomedicine. 2013 Sep 15;20 (12) :1082-7.|[3]Nagatsu T, et al. Neuromelanin in Parkinson's Disease: Tyrosine Hydroxylase and Tyrosinase. Int J Mol Sci. 2022 Apr 10;23 (8) :4176.