Rhodiolin

Rhodiolin, a flavonoid, is an orally active glucose 6-phosphate isomerase (GPI) inhibitor. Rhodiolin inhibits papillary thyroid cancer (PTC) by targeting glycolysis enzyme glucose 6-phosphate isomerase GPI and suppressing PI3K/AKT/mTOR phosphorylation and induce apoptosis. Rhodiolin as a NS2B-NS3 protease inhibitor can disrupt dengue viral replication. Rhodiolin is also a potential candidate for developing anticancer strategies inhibiting CK1ε kinase. Rhodiolin can be used for the study of anti-tumor and anti-viral [1][2][3].

Product Specifications

CAS Number

[86831-53-0]

UNSPSC

12352005

Target

Akt; Apoptosis; Casein Kinase; Flavivirus; Glucose-6-Phosphate Isomerase (GPI) ; mTOR; PI3K; Virus Protease

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/rhodiolin.html

Purity

98.92

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(O)C=C(O[C@H](C3=CC(OC)=C(O)C=C3)[C@@H](CO)O4)C4=C2OC(C5=CC=C(O)C=C5)=C1O

Molecular Formula

C25H20O10

Molecular Weight

480.42

References & Citations

[1]Bo J, et al. Rhodiolin inhibits the PI3K/AKT/mTOR signaling pathway via the glycolytic enzyme GPI in human papillary thyroid cancer. Phytomedicine. 2024 Sep;132:155804.|[2]Hakami MA, et al. Identification of potential casein kinase I isoform epsilon inhibitors from phytoconstituents: implications for targeted anticancer therapeutics. J Biomol Struct Dyn. 2025 Apr 29:1-13. |[3]Purohit P, et al. Targeting the DENV NS2B-NS3 protease with active antiviral phytocompounds: structure-based virtual screening, molecular docking and molecular dynamics simulation studies. J Mol Model. 2022 Oct 24;28 (11) :365.