Saccharin (sodium)

Saccharin sodium is an orally active, non-caloric artificial sweetener (NAS) . Saccharin sodium has bacteriostatic and microbiome-modulating properties. Saccharin binds to and signals via specific taste receptors, not only in the oral cavity but also alongside the gastrointestinal tract. Saccharin has been reported to bind the human and rodent heteromeric guanine nucleotide-binding protein (G protein) coupled sweet taste receptors T1R2/T2R3 as well as the human bitter taste receptor T2R43 and T2R44. Saccharin can inhibit bacterial growth in vitro[1].

Product Specifications

CAS Number

[128-44-9]

UNSPSC

12352005

Hazard Statement

H302, H312, H315, H319, H332, H335, H350

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/saccharin-sodium.html

Purity

99.90

Solubility

H2O : 175 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC=C12)N([Na])S2(=O)=O

Molecular Formula

C7H4NNaO3S

Molecular Weight

205.17

Precautions

H302, H312, H315, H319, H332, H335, H350

References & Citations

[1]Sünderhauf A, et al. Saccharin Supplementation Inhibits Bacterial Growth and Reduces Experimental Colitis in Mice. Nutrients. 2020 Apr 17;12 (4) . pii: E1122.