1A-116
1A-116, a potent Rac1 inhibitor, is specific for W56 residues, can prevent EGF-induced Rac1 activation and block Rac1-P-Rex1 interaction. 1A-116 can induce apoptosis and inhibit cell proliferation, migration and cycle progression in a concentration-dependent manner. 1A-116 also demonstrates a high antimetastatic activity in vivo[1][2][3].
Product Specifications
CAS Number
1430208-73-3
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; Ras
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/1A-116.html
Purity
99.72
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N=C(NC1=CC=CC=C1C(F)(F)F)NC2=CC(C)=CC(C)=C2
Molecular Formula
C16H16F3N3
Molecular Weight
307.31
Precautions
H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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