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DDR2 Recombinant Rabbit Monoclonal Antibody [JE31-45]

Discoidin domain-containing receptor 2, also known as CD167b (cluster of differentiation 167b), is a protein that in humans is encoded by the DDR2 gene. Discoidin domain-containing receptor 2 is a receptor tyrosine kinase (RTK). RTKs play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. In the case of DDR2, the ligand is collagen which binds to its extracellular discoidin domain. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. DDR2 has been associated with a number of diseases including fibrosis and cancer.

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

CD167 antigen-like family member B antibody CD167b antibody CD167b antigen antibody Cell migration inducing protein 20 antibody DDR 2 antibody DDR2 antibody DDR2_HUMAN antibody Discoidin domain containing receptor 2 antibody Discoidin domain receptor 2 antibody Discoidin domain receptor family member 2 antibody discoidin domain receptor tyrosine kinase 2 antibody Discoidin domain-containing receptor 2 antibody discoidin domain-containing receptor tyrosine kinase 2 antibody Hydroxyaryl protein kinase antibody MIG20a antibody Migration inducing gene 16 protein antibody Neurotrophic tyrosine kinase antibody Neurotrophic tyrosine kinase receptor related 3 antibody NTRKR 3 antibody NTRKR3 antibody Receptor protein tyrosine kinase TKT antibody Receptor protein-tyrosine kinase TKT antibody Receptor related 3 antibody receptor-related 3 antibody TKT antibody TYRO 10 antibody TYRO10 antibody Tyrosine kinase receptor related to neurotrophic TRK antibody Tyrosine protein kinase TYRO 10 antibody Tyrosine protein kinase TYRO10 antibody Tyrosine-protein kinase TYRO10 antibody Tyrosylprotein kinase antibody

Abbreviation

DDR2, NTRKR3, TKT, TYRO10

Swiss Prot

Q16832 Human, Q62371 Mouse,

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide within Human DDR2 aa 806-855 / 855.

Isotype

IgG

Clone

JE31-45

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

HeLa cell lysate, SH-SY5Y cell lysate, L929 cell lysate, NIH/3T3 cell lysate, U-2 OS cell lysate, A375 cell lysate, PC-12 cell lysate, rat skeletal muscle tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IHC-P: 1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 97 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes

Frequently Asked Questions

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