AMDE-1
AMDE-1 is a potent autophagy inducer. AMDE-1 induces autophagy by the AMPK-mTORC1-ULK1 pathway and at the same time inhibited autophagy-mediated degradation by causing lysosome dysfunction. AMDE-1 can be used in research of cancer[1].
Product Specifications
CAS Number
[478043-30-0]
UNSPSC
12352005
Target
AMPK; Autophagy
Type
Reference compound
Related Pathways
Autophagy; Epigenetics; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/amde-1.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC(C1=NC2=NC(C(F)(F)F)=CC(C(F)(F)F)=C2C=C1)C3=CC=CC(Cl)=C3
Molecular Formula
C18H8ClF6N3
Molecular Weight
415.72
References & Citations
[1]Li M, et, al. AMDE-1 is a dual function chemical for autophagy activation and inhibition. PLoS One. 2015 Apr 20;10 (3) :e0122083.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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