PKCζ-IN-1
PKCζ-IN-1 is a compound that inhibits PKCζ and CDK2, showing an IC50 value of 5.18 nM for PKCζ and 1.04 μM for CDK2, with significant selectivity of 200-fold. PKCζ-IN-1 can reduce the activity of CDK2 while inhibiting PKCζ.
Product Specifications
CAS Number
[1132609-87-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CDK; PKC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pkcζ-in-1.html
Purity
99.1
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN(CC1)CCN1C2=CC=CC3=C2NC(C4=NNC5=C4C=CC(C6=CC=C(N)C=C6)=C5)=N3
Molecular Formula
C25H25N7
Molecular Weight
423.51
Precautions
H302, H315, H319, H335
References & Citations
[1]2- (6-Phenyl-1H-indazol-3-yl) -1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-f inhibitor
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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