MM 419447
MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C) [1].
Product Specifications
CAS Number
1092457-78-7
UNSPSC
12352209
Target
Guanylate Cyclase
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/mm-419447.html
Purity
98.69
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[CCEYCCNPACTGC(Disulfidebridge:Cys1-Cys6;Cys2-Cys10;Cys5-Cys13)]
Molecular Formula
C50H70N14O19S6
Molecular Weight
1363.56
References & Citations
[1]Busby RW, et al. Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation. J Pharmacol Exp Ther. 2013;344 (1) :196-206.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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