Ciliobrevin A
Ciliobrevin A (HPI-4) is a hedgehog (Hh) signaling pathway inhibitor with median inhibitory concentration (IC50) less than 10 μM[1].
Product Specifications
CAS Number
[302803-72-1]
Product Name Alternative
HPI-4
UNSPSC
12352005
Hazard Statement
H302, H410
Target
Hedgehog
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Ciliobrevin-A.html
Concentration
10mM
Purity
98.57
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#C/C(C(C1=CC=C(Cl)C=C1Cl)=O)=C(N2)\NC3=C(C=CC=C3)C2=O
Molecular Formula
C17H9Cl2N3O2
Molecular Weight
358.18
Precautions
H302, H410
References & Citations
[1]Hyman JM, et al. Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc Natl Acad Sci U S A. 2009 Aug 18;106 (33) :14132-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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