244cis

244cis, a piperazine-containing ionizable cationic lipid, has been used to generate lipid nanoparticles (LNPs) . LNPs containing 244cis and coated with mRNA reporter gene were specifically accumulated in mouse lungs compared with LNPs containing SM-102. Induces a decrease in serum chemokine (C-C motif) ligand 2 (CCL2) levels[1].

Product Specifications

CAS Number

[2956402-64-3]

UNSPSC

12352200

Target

Liposome

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/244cis.html

Concentration

25.76 mM * 40 μL in Ethanol

Purity

96.70

Solubility

10 mM in DMSO

Smiles

CCCCCC/C=C\COC(CCCCCCCCN(CCCCCCCCC(OC/C=C\CCCCCC)=O)CCN1CCN(CC1)CCCCCCCCC(OC/C=C\CCCCCC)=O)=O

Molecular Formula

C60H111N3O6

Molecular Weight

970.54

References & Citations

[1]Kim M, et al. Novel piperazine-based ionizable lipid nanoparticles allow the repeated dose of mRNA to fibrotic lungs with improved potency and safety. Bioeng Transl Med. 2023 May 28;8 (6) :e10556.