3′-Deoxyguanosine

3′-Deoxyguanosine (Guanosine, 3'-deoxy-) is a derivative of Guanosine (HY-N0097) . 3′-Deoxyguanosine interacts with human purine nucleoside phosphorylase via hydrogen bonding with residues such as Glu201 and Asn243. 3′-Deoxyguanosine exhibits moderate displacement activity for [3H]-guanosine in rat meninges. 3′-Deoxyguanosine is useful for studying the mechanism of guanosine receptors and purine metabolism[1][2][3].

Product Specifications

CAS Number

[3608-58-0]

Product Name Alternative

Guanosine, 3'-deoxy-

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Derivative; Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Others

Applications

Cancer-programmed cell death

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/3-deoxyguanosine.html

Purity

97.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC[C@@H]1C[C@@H](O)[C@H](N2C(N=C(N)NC3=O)=C3N=C2)O1

Molecular Formula

C10H13N5O4

Molecular Weight

267.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Traversa U, et al. Rat brain guanosine binding site. Biological studies and pseudo-receptor construction. Bioorg Med Chem. 2003 Dec 1;11 (24) :5417-25.|[2]Canduri F, et al. Structure of human PNP complexed with ligands. Acta Crystallogr D Biol Crystallogr. 2005 Jul;61 (Pt 7) :856-62.|[3]King RW, et al. Inhibition of the replication of a hepatitis C virus-like RNA template by interferon and 3'-deoxycytidine. Antivir Chem Chemother. 2002 Nov;13 (6) :363-70.