Rotenolone

Rotenolone is an antiproliferative agent. Rotenolone shows antiproliferative activity against the ovarian cancer A2780, breast cancer BT-549, prostate cancer DU 145, NSCLC NCI-H460, and colon cancer HCC-2998 cell lines, with IC50s of 0.95, 1.6, 2.7, 2.0, and 2.9 μM, respectively[1].

Product Specifications

CAS Number

[509-96-6]

UNSPSC

12352005

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rotenolone.html

Purity

97.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1[C@@]2([C@]([H])(OC3=C1C=CC4=C3C[C@@H](O4)C(C)=C)COC5=C2C=C(C(OC)=C5)OC)O

Molecular Formula

C23H22O7

Molecular Weight

410.42

References & Citations

[1]Harinantenaina L, et, al. Antiproliferative compounds from Pongamiopsis pervilleana from the Madagascar Dry Forest. J Nat Prod. 2010 Sep 24;73 (9) :1559-62.