Z36-MP5
Z36-MP5 is an Mi-2β-targeted inhibitor, with IC50 of 0.082 μM. Z36-MP5 can reduce Mi-2β ATPase activity and reactivates ISG transcription. Z36-MP5 can stimulate T-cell-mediated cytotoxicity[1].
Product Specifications
CAS Number
[2839660-03-4]
UNSPSC
12352005
Target
IFNAR
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/z36-mp5.html
Concentration
10mM
Purity
99.74
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1CC2=NC=CN2CC1)C3=CC(C4=CC=C(NC(N5C)=O)C5=C4)=CC=C3
Molecular Formula
C22H21N5O2
Molecular Weight
387.43
References & Citations
[1]Cang Li, et al. Mi-2β promotes immune evasion in melanoma by activating EZH2 methylation. Nat Commun. 2024 Mar 9;15 (1) :2163.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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