GSK840
GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 0.9 nM, and inhibits kinase activity with an IC50 of 0.3 nM[1].
Product Specifications
CAS Number
2361146-30-5
Product Name Alternative
GSK'840
UNSPSC
12352005
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gsk840.html
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OC(C)(C)C)CC1=CC=C(N2C3=CC=C(C(NC)=O)C=C3N=C2)C=C1
Molecular Formula
C21H23N3O3
Molecular Weight
365.43
References & Citations
[1]Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20;56 (4) :481-95.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK3
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![VPAC1 Recombinant Rabbit Monoclonal Antibody [PD00-96]](https://cdn.genprice.uk/products/992/68dd1c8a061270361ea8126a/imageurl/ha721209.webp)
HA721209 100 µL
VPAC1 Recombinant Rabbit Monoclonal Antibody [PD00-96]
Sign In for Pricing
View Details 
LY419655 100 µg
Decorin (DCN) (NM_001920) Human Over-expression Lysate
Sign In for Pricing
View Details 
BNUM2878-50 1x 50 µL
Ornithine Decarboxylase-1 (ODC-1) (ODC1/2878R), 1mg/mL
Sign In for Pricing
View Details