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NIR-Red Dead Cell-1 Dye

NIR-Red Dead Cell-1 Dye is a DNA-binding fluorescent dye for non-living cells (Ex/Em=515 nm/531 nm) . NIR-Red Dead Cell-1 Dye can intercalate into base pairs of double-stranded DNA and produce stronger fluorescence. NIR-Red Dead Cell-1 Dye is suitable for necrotic cells or late apoptotic cells with damaged cell membranes, showing green fluorescence under fluorescence microscopy or flow cytometry. NIR-Red Dead Cell-1 Dye can be used to distinguish live cells from dead cells and distinguish cell membrane integrity. NIR-Red Dead Cell-1 Dye can be attached to the surface of Feraheme (FH) nanoparticles (NPs) to obtain fluorescent dye-functionalized NPs for drug delivery studies[1][2][3].

Product Specifications

CAS Number

[157199-59-2]

UNSPSC

12171500

Target

DNA Stain

Type

Dye Reagents

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/to-pro-1.html

Concentration

5 mM * 50 μL in DMSO

Purity

96.0

Solubility

10 mM in DMSO

Smiles

C[N+](CCC[N+]1=C2C=CC=CC2=C(/C=C3SC4=CC=CC=C4N\3C)C=C1)(C)C.[I-].[I-]

Molecular Formula

C24H29I2N3S

Molecular Weight

645.38

References & Citations

[1]Hoonsung Cho, et al. Fluorochrome-functionalized nanoparticles for imaging DNA in biological systems. ACS Nano. 2013 Mar 26;7 (3) :2032-41.|[2]Gorokhova E, et al. A comparison of TO-PRO-1 iodide and 5-CFDA-AM staining methods for assessing viability of planktonic algae with epifluorescence microscopy. J Microbiol Methods. 2012 Jun;89 (3) :216-21.|[3]Okochi M, et al. Fluorometric observation of viable and dead adhering diatoms using TO-PRO-1 iodide and its application to the estimation of electrochemical treatment. Applied microbiology and biotechnology 51 (1999) : 364-369.

Shipping Conditions

Blue Ice

Storage Conditions

Solution, -20°C, protect from light, 2 years

Scientific Category

Dye Reagents

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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