Dictamine

Dictamnine (Dictamine) exhibits cytotoxicity to human cervical and colon cancer cells and also has antibacterial and antifungal activities[1].

Product Specifications

CAS Number

[484-29-7]

Product Name Alternative

Dictamnine; Dectamine

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Apoptosis; Bacterial; Fungal

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dictamine.html

Purity

99.60

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

COC1=C2C(OC=C2)=NC3=CC=CC=C13

Molecular Formula

C12H9NO2

Molecular Weight

199.21

Precautions

H302, H315, H319

References & Citations

[1]Guo N, et al. Global gene expression profile of Saccharomyces cerevisiae induced by dictamnine. Yeast. 2008 Sep;25 (9) :631-41.|[2]An FF, et al. Dihydroartemisinine enhances dictamnine-induced apoptosis via a caspase dependent pathway in human lung adenocarcinoma A549 cells. Asian Pac J Cancer Prev. 2013;14 (10) :5895-900.|[3]Lin CY, et al. Dictamnine delivered by PLGA nanocarriers ameliorated inflammation in an oxazolone-induced dermatitis mouse model. J Control Release. 2021 Jan 10;329:731-742.|[4]Wang JY, et al. Dictamnine promotes apoptosis and inhibits epithelial-mesenchymal transition, migration, invasion and proliferation by downregulating the HIF-1α and Slug signaling pathways. Chem Biol Interact. 2018 Dec 25;296:134-144. |[5]Yang N, et al. Dictamnine ameliorates chronic itch in DNFB-induced atopic dermatitis mice via inhibiting MrgprA3. Biochem Pharmacol. 2023 Feb;208:115368.