IL-11R alpha, Human (HEK293, His)

IL-11R alpha (IL-11RA) is the IL-11 receptor subunit α and also acts as an agonist of IL-11. IL-11R alpha binds to IL6ST/gp130 on cell surfaces and induces signal transduction[1]. IL-11R alpha activates Jak family of tyrosine kinases, JAK1, JAK2, and TYK2[3]. IL-11R alpha induces proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells[4]. IL-11R alpha plays an important role in the progression and the differentiation of human gastric carcinomas[5]. IL-11R alpha Protein, Human (HEK293, His) is a recombinant protein with a His label that consists of 341 amino acids (S23-V363) and is produced by HEK293 cells.

SSPCPQAWGP PGVQYGQPGR SVKLCCPGVT AGDPVSWFRD GEPKLLQGPD SGLGHELVLA QADSTDEGTY ICQTLDGALG GTVTLQLGYP PARPVVSCQA ADYENFSCTW SPSQISGLPT RYLTSYRKKT VLGADSQRRS PSTGPWPCPQ DPLGAARCVV HGAEFWSQYR INVTEVNPLG ASTRLLDVSL QSILRPDPPQ GLRVESVPGY PRRLRASWTY PASWPCQPHF LLKFRLQYRP AQHPAWSTVE PAGLEEVITD AVAGLPHAVR VSARDFLDAG TWSTWSPEAW GTPSTGTIPK EIPAWGQLHT QPEVEPQVDS PAPPRPSLQP HPRLLDHRDS V

[1]Schafer S, et al. IL-11 is a crucial determinant of cardiovascular fibrosis. Nature. 2017 Dec 7;552(7683):110-115.|[2]Cook SA, et al. Hiding in Plain Sight: Interleukin-11 Emerges as a Master Regulator of Fibrosis, Tissue Integrity, and Stromal Inflammation. Annu Rev Med. 2020 Jan 27;71:263-276.|[3]Balakrishnan L, et al. IL-11/IL11RA receptor mediated signaling: a web accessible knowledgebase. Cell Commun Adhes. 2013 Aug;20(3-4):81-6.|[4]Dams-Kozlowska H, et al. A designer hyper interleukin 11 (H11) is a biologically active cytokine. BMC Biotechnol. 2012 Mar 21;12:8.|[5]Nakayama T, et al. Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the invasive activity of human gastric carcinoma cells. Int J Oncol. 2007 Apr;30(4):825-33.