Orphanin FQ (1-11)

Orphanin FQ (1-11), a orphanin FQ or nociceptin (OFQ/N) fragment, is a potent NOP receptor (ORL-1; OP4) agonist, with a Ki of 55 nM. Orphanin FQ (1-11) has no affinity for μ, δ, κ1 and κ3 receptors (Ki>1000 nM) . Orphanin FQ (1-11) is analgesic in CD-1 mice[1][2].

Product Specifications

CAS Number

[178249-41-7]

UNSPSC

12352209

Target

Opioid Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/orphanin-fq-1-11.html

Purity

99.52

Solubility

H2O : ≥ 100 mg/mL

Smiles

O=C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=CC=C2)N

Molecular Formula

C49H75N15O14

Molecular Weight

1098.21

References & Citations

[1]Reinscheid RK, et al. Structure-activity relationship studies on the novel neuropeptide orphanin FQ. J Biol Chem. 1996;271 (24) :14163-14168.|[2]Rossi GC, et al. Pharmacological characterization of orphanin FQ/nociceptin and its fragments. J Pharmacol Exp Ther. 1997;282 (2) :858-865.