GBM CSCs-IN-1
GBM CSCs-IN-1 (Compound (−) -20), a derivative of rocaglate, is a potent inhibitor of glioblastoma stem cells (GBM CSCs) with an EC50 of 45 nM, functioning by targeting the RNA helicase DDX3. Furthermore, GBM CSCs-IN-1 is also capable of inducing apoptosis[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gbm-cscs-in-1.html
Smiles
COC1=C2C(O[C@]3(C4=CC=C(Br)C=C4)[C@@]2(O)[C@H](O)[C@H](C(NS(N(C)C)(=O)=O)=O)[C@H]3C5=CC=CC=C5)=CC(OC)=C1
Molecular Formula
C28H29BrN2O8S
Molecular Weight
633.51
References & Citations
[1]Wang Z, et al. Identification of Rocaglate Acyl Sulfamides as Selective Inhibitors of Glioblastoma Stem Cells[J]. ACS Central Science, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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