PRLX-93936 (dihydrochloride)
PRLX-93936 dihydrochloride (Compound 16) is a HIF-1α inhibitor with anticancer activity. PRLX-93936 can inhibit the activated Ras pathway and can be used in the study of relapsed or refractory multiple myeloma[1][2].
Product Specifications
CAS Number
1094210-96-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
HIF/HIF Prolyl-Hydroxylase; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/prlx-93936-dihydrochloride.html
Purity
99.83
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1N(C(CN2CCNCC2)=NC3=C1C=CC=C3)C4=CC=CC=C4OCC.Cl.Cl
Molecular Formula
C21H26Cl2N4O2
Molecular Weight
437.36
Precautions
H302, H315, H319
References & Citations
[1]Huang W, et al. Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1α inhibitors. Bioorg Med Chem Lett. 2011 Sep 15;21 (18) :5239-43.|[2]Voorhees P M, et al. An open-label, dose escalation, multi-center phase 1 study of PRLX 93936, an agent synthetically active against the activated ras pathway, in the treatment of relapsed or relapsed and refractory multiple myeloma[J]. Blood, 2014, 124 (21) : 2140.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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