Human Prothrombin witout GLA Domain

<strong>Human Prothrombin witout GLA Domain</strong>_x000D_ <strong>Catalog number:</strong> B2013215_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 5 mg_x000D_ <strong>Molecular Weight or Concentration:</strong> na_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20° C_x000D_ <strong>Keywords:</strong> Human Prothrombin-gla domainless_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Winter WE, Flax SD, Harris NS. Coagulation Testing in the Core Laboratory Lab Med. 2017 Nov 8;48(4):295-313._x000D_ 2: Blostein MD, Rigby AC, Jacobs M, Furie B, Furie BC. The Gla domain of human prothrombin has a binding site for factor Va J Biol Chem. 2000 Dec 1;275(48):38120-6._x000D_ 3: Tokunaga F, Takeuchi S, Omura S, Arvan P, Koide T. Secretion, gamma-carboxylation, and endoplasmic reticulum-associated degradation of chimeras with mutually exchanged Gla domain between human protein C and prothrombin Thromb Res. 2000 Sep 1;99(5):511-21._x000D_ 4: Wu W, Bancroft JD, Suttie JW. Structural features of the kringle domain determine the intracellular degradation of under-gamma-carboxylated prothrombin: studies of chimeric rat/human prothrombin Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13654-60._x000D_ 5: Card DJ, Gorska R, Harrington DJ. Laboratory assessment of vitamin K status J Clin Pathol. 2020 Feb;73(2):70-75._x000D_ 6: Itoh S, Yokoyama R, Kamoshida G, Fujiwara T, Okada H, Takii T, Tsuji T, Fujii S, Hashizume H, Onozaki K. Staphylococcal superantigen-like protein 10 (SSL10) inhibits blood coagulation by binding to prothrombin and factor Xa via their γ-carboxyglutamic acid (Gla) domain J Biol Chem. 2013 Jul 26;288(30):21569-80._x000D_ 7: Soriano-Garcia M, Park CH, Tulinsky A, Ravichandran KG, Skrzypczak-Jankun E. Structure of Ca2+ prothrombin fragment 1 including the conformation of the Gla domain Biochemistry. 1989 Aug 22;28(17):6805-10._x000D_ 8: Qureshi SH, Yang L, Manithody C, Bae JS, Rezaie AR. Functional properties and active-site topographies of factor X Gla- and prothrombin Gla-domain chimeras of activated protein C Biochim Biophys Acta. 2008 Sep;1780(9):1080-6._x000D_ 9: Li L, Darden T, Hiskey R, Pedersen LG. Computational studies of human prothrombin fragment 1, the Gla domain of factor IX and several biological interesting mutants Haemostasis. 1996;26 Suppl 1:54-9._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/10556651">10: Uehara S, Gotoh K, Handa H, Honjo K, Hirayama A. Process of carboxylation of glutamic acid residues in the gla domain of human des-gamma-carboxyprothrombin Clin Chim Acta. 1999 Nov;289(1-2):33-44. </a>_x000D_ _x000D_ <strong>Products Related to Human Prothrombin witout GLA Domain can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>