AR antagonist 1 (hydrochloride)

AR antagonist 1 (compound 29) hydrochloride is a potent androgen receptor (AR) antagonist and binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266 (HY-133020) [1].

Product Specifications

CAS Number

[1818885-55-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Androgen Receptor; Ligands for E3 Ligase; Ligands for Target Protein for PROTAC

Type

Reference compound

Related Pathways

PROTAC; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ar-antagonist-1-hydrochloride.html

Purity

99.53

Solubility

DMSO : 58.33 mg/mL (ultrasonic)

Smiles

[H]Cl.N#CC1=CC=C(O[C@H]2C(C)(C)[C@H](N)C2(C)C)C=C1Cl

Molecular Formula

C15H20Cl2N2O

Molecular Weight

315.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Han X, et al. Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands. J Med Chem. 2019 Dec 26;62 (24) :11218-11231.