EP009
EP009 is a JAK3 inhibitor that selectively inhibits IL-2-mediated JAK3 tyrosine phosphorylation (IC50=10-20 μM in Kit225 cells) without affecting IL-3-induced JAK2 phosphorylation (up to 50 μM in BaF/3 cells) . EP009 significantly reduced Kit225 cell viability (72 h, LD50=5.0 μM) while having no effect on BaF/3 cells.[1].
Product Specifications
CAS Number
1462951-30-9
UNSPSC
12352211
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ep009.html
Smiles
O=C1C(CCCCCCCCCC1=C)CO
Molecular Formula
C14H24O2
Molecular Weight
224.34
References & Citations
[1]Inhibition of JAK3 with a novel, selective, and orally active small molecule induces therapeutic response in T-cell malignancies
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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