PR-104
PR-104 is a selective hypoxia-activated DNA cross-linking agent and can be used for the research of multiple tumor xenograft models. PR-104, as a nitrogen mustard pre-proagent, is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A[1].
Product Specifications
CAS Number
[851627-62-8]
UNSPSC
12352005
Target
DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pr-104.html
Purity
97.71
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 31.25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NCCOP(O)(O)=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1N(CCBr)CCOS(=O)(C)=O
Molecular Formula
C14H20BrN4O12PS
Molecular Weight
579.27
References & Citations
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, protect from light, stored under nitrogen
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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