PR-104

PR-104 is a selective hypoxia-activated DNA cross-linking agent and can be used for the research of multiple tumor xenograft models. PR-104, as a nitrogen mustard pre-proagent, is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A[1].

Product Specifications

CAS Number

[851627-62-8]

UNSPSC

12352005

Target

DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pr-104.html

Purity

97.71

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 31.25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NCCOP(O)(O)=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1N(CCBr)CCOS(=O)(C)=O

Molecular Formula

C14H20BrN4O12PS

Molecular Weight

579.27

References & Citations

[1]Patterson AV, et al. Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104. Clin Cancer Res. 2007;13 (13) :3922-3932.