LY2886721
LY2886721 is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 20.3 nM for recombinant human BACE1. LY2886721 is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2 (IC50 of 10.2 nM) . LY2886721 can across blood-brain barrier and has the potential for Alzheimer's disease treatment[1].
Product Specifications
CAS Number
[1262036-50-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/LY2886721.html
Purity
99.72
Solubility
DMSO : ≥ 16.67 mg/mL
Smiles
FC1=CN=C(C=C1)C(NC2=CC=C(C([C@@]34[C@]([H])(CSC(N)=N4)COC3)=C2)F)=O
Molecular Formula
C18H16F2N4O2S
Molecular Weight
390.41
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
BACE1
Available Sizes
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