LY2886721
LY2886721 is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 20.3 nM for recombinant human BACE1. LY2886721 is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2 (IC50 of 10.2 nM) . LY2886721 can across blood-brain barrier and has the potential for Alzheimer's disease treatment[1].
Product Specifications
CAS Number
[1262036-50-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/LY2886721.html
Purity
99.72
Solubility
DMSO : ≥ 16.67 mg/mL
Smiles
FC1=CN=C(C=C1)C(NC2=CC=C(C([C@@]34[C@]([H])(CSC(N)=N4)COC3)=C2)F)=O
Molecular Formula
C18H16F2N4O2S
Molecular Weight
390.41
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
BACE1
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
ZNF224, NT (ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27, Zinc finger protein 224, Bone marrow zinc finger 2, Zinc finger protein 233, Zinc finger protein 255, Zinc finger protein 27, Zinc finger protein KOX22) (APC) discontinued
