CHF5022

CHF5022 is an inhibitor of Aβ42 secretion (IC50=92 μM) . CHF5022 retains a modest activity on Aβ40 at non-cytotoxic concentrations (−22.2±4.8% at 100 μM) [1].

Product Specifications

CAS Number

749269-77-0

UNSPSC

12352005

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/chf5022.html

Smiles

O=C(C1(C2=CC=C(C3=CC=C(C(F)(F)F)C=C3)C(F)=C2)CC1)O

Molecular Formula

C17H12F4O2

Molecular Weight

324.27

References & Citations

[1]Imbimbo BP, et al. In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents. Pharmacol Res. 2007 Apr;55 (4) :318-28.