CHF5022
CHF5022 is an inhibitor of Aβ42 secretion (IC50=92 μM) . CHF5022 retains a modest activity on Aβ40 at non-cytotoxic concentrations (−22.2±4.8% at 100 μM) [1].
Product Specifications
CAS Number
749269-77-0
UNSPSC
12352005
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/chf5022.html
Smiles
O=C(C1(C2=CC=C(C3=CC=C(C(F)(F)F)C=C3)C(F)=C2)CC1)O
Molecular Formula
C17H12F4O2
Molecular Weight
324.27
References & Citations
[1]Imbimbo BP, et al. In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents. Pharmacol Res. 2007 Apr;55 (4) :318-28.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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