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(R) -DNMDP

(R) -DNMDP is a potent and selective cancer cell cytotoxic agent. (R) -DNMDP, the R-form of DNMDP, binds PDE3A directly. (R) -DNMDP has a 500-fold lower EC50 compared to the (S) -enantiomer in HeLa cell line[1][2].

Product Specifications

CAS Number

1630760-60-9

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/r-dnmdp.html

Purity

99.59

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C[C@@H](C)C(C2=CC=C(N(CC)CC)C([N+]([O-])=O)=C2)=NN1

Molecular Formula

C15H20N4O3

Molecular Weight

304.34

References & Citations

[1]de Waal L, et al. Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics. Nat Chem Biol. 2016 Feb;12 (2) :102-8. Nat Chem Biol. 2016 Feb;12 (2) :102-8.|[2]Luc DE WAAL, et al. Compositions and methods for cancer expressing pde3a or slfn12. WO2017027854A1.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PDE3

Available Sizes

Frequently Asked Questions

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