DT-2
DT-2 is a potent and selective inhibitor of the cGMP-dependent protein kinase (PKG) . DT-2 inhibits PKG catalyzed phosphorylation (Ki: 12.5 nM) [1].
Product Specifications
CAS Number
1220985-78-3
UNSPSC
12352209
Target
PKG
Type
Peptides
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dt-2.html
Solubility
10 mM in DMSO
Smiles
O=C(N1[C@@H](CCC1)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CC2=CN=CN2)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]3N(CCC3)C([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC(CNC([C@@H](N)CC4=CC=C(C=C4)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C122H223N53O23
Molecular Weight
2800.42
References & Citations
[1]Pinkse MWH, et al. Mode of action of cGMP-dependent protein kinase-specific inhibitors probed by photoaffinity cross-linking mass spectrometry. J Biol Chem. 2009 Jun 12;284 (24) :16354-16368.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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