Folic Acid (Biotechnology Grade)

<strong>Folic Acid</strong>_x000D_ <strong>Catalog number:</strong> B2010164_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Volume/Weight:</strong> 1 g_x000D_ <strong>pH:</strong> na_x000D_ <strong>Supplied as:</strong> Ready-to-use_x000D_ <strong>Appearance:</strong> Yellow/Orange powder_x000D_ <strong>Applications:</strong> as substrate for dihydrofolate reductase(s) reactions. Through its convertion into Tetrahydrofolate (THF), Folic Acid is required for de novo synthesis of purines, thymidylic acid and various amino acids as well as for the post-translational methylation od DNA which one of the basis of epigenetics._x000D_ <strong>Storage:</strong> room temperature_x000D_ <strong>Keywords:</strong> PteGlu, Pteroyl-L-glutamic acid, Vitamin M, Vitamin B9._x000D_ <strong>Grade:</strong> Biotechnology grade. All components are highly pure (minimum 99%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered on a 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Shao D, Li J, Pan Y, Zhang X, Zheng X, Wang Z, Zhang M, Zhang H, Chen L._x000D_ Noninvasive theranostic imaging of HSV-TK/GCV suicide gene therapy in liver_x000D_ cancer by folate-targeted quantum dot-based liposomes. Biomater Sci. 2015_x000D_ Jun;3(6):833-41._x000D_ _x000D_ 2: Fu L. Use of Smartphone Funduscopy to aid Diagnosis of chorioretinitis after_x000D_ donor-recipient mismatched cardiac transplantation. BMJ Case Rep. 2017 Sep_x000D_ 25;2017:bcr2017221981._x000D_ _x000D_ 3: Shanley JD, Debs RJ. The folate antagonist, methotrexate, is a potent_x000D_ inhibitor of murine and human cytomegalovirus in vitro. Antiviral Res. 1989_x000D_ Mar;11(2):99-106._x000D_ _x000D_ 4: Israel DS, Plaisance KI. Neutropenia in patients infected with human_x000D_ immunodeficiency virus. Clin Pharm. 1991 Apr;10(4):268-79._x000D_ _x000D_ 5: Walzer PD, Foy J, Steele P, Kim CK, White M, Klein RS, Otter BA, Allegra C._x000D_ Activities of antifolate, antiviral, and other drugs in an immunosuppressed rat_x000D_ model of Pneumocystis carinii pneumonia. Antimicrob Agents Chemother. 1992_x000D_ Sep;36(9):1935-42._x000D_ _x000D_ 6: Mayer-Kuckuk P, Banerjee D, Malhotra S, Doubrovin M, Iwamoto M, Akhurst T,_x000D_ Balatoni J, Bornmann W, Finn R, Larson S, Fong Y, Gelovani Tjuvajev J, Blasberg_x000D_ R, Bertino JR. Cells exposed to antifolates show increased cellular levels of_x000D_ proteins fused to dihydrofolate reductase: a method to modulate gene expression._x000D_ Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3400-5._x000D_ _x000D_ 7: Prichard MN, Prichard LE, Shipman C Jr. Inhibitors of thymidylate synthase_x000D_ and dihydrofolate reductase potentiate the antiviral effect of acyclovir._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/8385896/">Antiviral Res.</a> 1993 Mar;20(3):249-59._x000D_ _x000D_ <strong>Products Related to Folic Acid </strong> <a>: Biochemical Buffers and Solutions</a>