MY33-3 (hydrochloride)

MY33-3 hydrochloride is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP) β/ζ, with an IC50 of ~0.1 μM. MY33-3 hydrochloride also inhibits PTP-1B (IC50 ~0.7 μM) . MY33-3 hydrochloride can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction[1][2][3].

Product Specifications

CAS Number

[2204280-42-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/my33-3-hydrochloride.html

Purity

99.32

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC(F)(SC1=CC=C(CNCC2=CC=C(C=C2)SC(F)(F)F)C=C1)F.Cl

Molecular Formula

C16H14ClF6NS2

Molecular Weight

433.86

Precautions

H302, H315, H319, H335

References & Citations

[1]Fernández-Calle R, et, al. Pharmacological inhibition of Receptor Protein Tyrosine Phosphatase β/ζ (PTPRZ1) modulates behavioral responses to ethanol. Neuropharmacology. 2018 Jul 15;137:86-95. |[2]Fernández-Calle R, et, al. Role of RPTPβ/ζ in neuroinflammation and microglia-neuron communication. Sci Rep. 2020 Nov 20;10 (1) :20259. |[3]Mao S, et, al. Pleiotrophin Potentiates Sevoflurane Anesthesia-induced Learning Deficits in Mice. J Mol Neurosci. 2022 Jan;72 (1) :48-55.