Glicoricone
Glicoricone, a phenolic compound, is isolated from a species of licorice. Glicoricone is an inhibitor of monoamine oxidase (MAO), with an IC50 of 140 μM. Glicoricone binds to estrogen receptor (ER) and shows estrogen antagonist activity[1][2].
Product Specifications
CAS Number
161099-37-2
UNSPSC
12352005
Target
Estrogen Receptor/ERR; Monoamine Oxidase
Type
Natural Products
Related Pathways
Neuronal Signaling; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/glicoricone.html
Purity
96.0
Solubility
10 mM in DMSO
Smiles
O=C1C(C2=C(O)C=C(O)C(C/C=C(C)\C)=C2OC)=COC3=CC(O)=CC=C13
Molecular Formula
C21H20O6
Molecular Weight
368.38
References & Citations
[1]Hatano T, et, al. Phenolic constituents of licorice. III. Structures of glicoricone and licofuranone, and inhibitory effects of licorice constituents on monoamine oxidase. Chem Pharm Bull (Tokyo) . 1991 May;39 (5) :1238-43.|[2]Boonmuen N, et, al. Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities. Steroids. 2016 Jan;105:42-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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