JNJ-1930942

JNJ-1930942 is a selective and blood-brain barrier (BBB) penetrant α (7) nAChR positive allosteric modulator.JNJ-1930942 enhances the Choline (HY-B0282) -evoked rise in intracellular Ca2+ levels and neurotransmission at hippocampal dentate gyrus synapses. JNJ-1930942 reverses the naturally occurring sensory gating deficit in DBA/2 mice[1].

Product Specifications

CAS Number

[929562-28-7]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/jnj-1930942.html

Smiles

OCC1=C(C2=CC=NC=C2)N=C(NC3=CC=C(F)C(C(F)(F)F)=C3)S1

Molecular Formula

C16H11F4N3OS

Molecular Weight

369.34

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Dinklo T, et al. Characterization of 2-[[4-fluoro-3- (trifluoromethyl) phenyl]amino]-4- (4-pyridinyl) -5-thiazolemethanol (JNJ-1930942), a novel positive allosteric modulator of the {alpha}7 nicotinic acetylcholine receptor. J Pharmacol Exp Ther. 2011;336 (2) :560-574.