His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 (TFA)

His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA, is a growth hormone releasing peptide, as well as a metabolite of GHRP-1. GHRP-1, or Ala-His-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2, has the effect of promoting the release of growth hormone (GH) . GHRP-1 increases GH release and increases [Ca2+]i levels in static monolayer cells of rat pituitary gland, but does not affect cAMP levels[1].

Product Specifications

UNSPSC

12352209

Target

Cholinesterase (ChE) ; Endogenous Metabolite

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/his-d-beta-nal-ala-trp-d-phe-lys-nh2-tfa.html

Purity

99.56

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NCCCC[C@@H](C(N)=O)NC([C@@H](CC1=CC=CC=C1)NC([C@@H](NC([C@H](C)NC([C@H](NC([C@@H](N)CC2=CN=CN2)=O)CC3=CC4=C(C=CC=C4)C=C3)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O.OC(C(F)(F)F)=O

Molecular Formula

C50H58F3N11O8

Molecular Weight

998.06

References & Citations

[1]Akman MS, et al. Mechanisms of action of a second generation growth hormone-releasing peptide (Ala-His-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2) in rat anterior pituitary cells. Endocrinology. 1993 Mar;132 (3) :1286-91.