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TINK-IN-1

TINK-IN-1 (Compound 9) is a potent and selective Traf2- and Nck-interacting kinase (TNIK) inhibitor with an IC50 of 8 nM. TINK-IN-1 inhibits colorectal cancer cells viability[1].

Product Specifications

CAS Number

1417795-25-5

UNSPSC

12352005

Target

MAP4K

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tink-in-1.html

Purity

98.02

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

N#CC1=CC(C2=CC(NC3=CC=C(N4CCOCC4)C(OC)=C3)=NC=C2)=C(OC)C=C1

Molecular Formula

C24H24N4O3

Molecular Weight

416.47

References & Citations

[1]Ho KK, et al. Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors. Bioorg Med Chem Lett. 2013 Jan 15;23 (2) :569-73.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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