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PD-1/PD-L1-IN-29

PD-1/PD-L1-IN-29 (S4-1) is a potent PD-1/PD-L1 inhibitor with an IC50 value of 6.1 nM. PD-1/PD-L1-IN-29 binds PD-L1 and disrupts PD-1/PD-L1 interactions, induces PD-L1 dimerization and internalization, improves its localization to the endoplasmic reticulum, and promotes PD-L1 entry into the endoplasmic reticulum. PD-1/PD-L1-IN-29 has anticancer activity[1].

Product Specifications

CAS Number

2665734-13-2

UNSPSC

12352005

Target

PD-1/PD-L1

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pd-1-pd-l1-in-29.html

Purity

99.87

Solubility

DMSO : 66.67 mg/mL (ultrasonic; adjust pH to 2 with 1M HCl)

Smiles

OC[C@H](NCC1=CC2=C(C=C1OC)C(N(C2=O)C3=C(C(C4=CC=CC=C4)=CC=C3)C)=O)C(O)=O

Molecular Formula

C26H24N2O6

Molecular Weight

460.48

References & Citations

[1]Chengliang Sun, et al. Novel Small-Molecule PD-L1 Inhibitor Induces PD-L1 Internalization and Optimizes the Immune Microenvironment. J Med Chem. 2022 Dec 29.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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