L-Selenocystine

L-Selenocystine is a selenium-containing amino acid. L-Selenocystine has redox properties. L-Selenocystine is cytotoxic to various tumor cells and can induce the production of ROS and apoptosis. L-Selenocystine can block the Nrf2 and autophagy pathways. L-Selenocystine has anti-tumor activity[1][2][3][4].

Product Specifications

CAS Number

[29621-88-3]

UNSPSC

12352209

Hazard Statement

H301+H331, H373, H410

Target

Apoptosis; Autophagy; Bcl-2 Family; Caspase; Keap1-Nrf2; p62; Reactive Oxygen Species (ROS)

Type

Peptides

Related Pathways

Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/l-selenocystine.html

Purity

98.0

Solubility

H2O : 5.88 mg/mL (ultrasonic; warming; adjust pH to 1 with HCl; heat to 60°C)

Smiles

N[C@@H](C[Se][Se]C[C@@H](C(O)=O)N)C(O)=O

Molecular Formula

C6H12N2O4Se2

Molecular Weight

334.09

Precautions

H301+H331, H373, H410

References & Citations

[1]Michio Iwaoka, et al. Synthesis of selenocysteine and selenomethionine derivatives from sulfur-containing amino acids. Chem Biodivers. 2008 Mar;5 (3) :359-74.Michio Iwaoka, et al. Synthesis of selenocysteine and selenomethionine derivatives from sulfur-containing amino acids. Chem Biodivers. 2008 Mar;5 (3) :359-74.|[2]Roy J, et al. Optically active selenium-containing amino acids. The synthesis of L-selenocystine and L-selenolanthionine. J Org Chem. 1970 Feb;35 (2) :510-3.|[3]CHEN H, et al. L-Selenocystine induce HepG2 cells apoptosis through ROS-mediated signaling pathways. Biocell, 2022, 46 (10) .|[4]Hsu WL, et al. Blockage of Nrf2 and autophagy by L-selenocystine induces selective death in Nrf2-addicted colorectal cancer cells through p62-Keap-1-Nrf2 axis. Cell Death Dis. 2022 Dec 20;13 (12) :1060.