XJTU-L453
XJTU-L453 is a PI3Kα inhibitor with an IC50 value of 0.4 nM. XJTU-L453 can inhibit the proliferation of breast cancer cell lines T47D and MCF7, with IC50 values of 0.2 μM and 0.5 μM, respectively. XJTU-L453 can inhibit the PI3K pathway, induce cell cycle arrest, and trigger cell apoptosis (apoptosis) . XJTU-L453 also has antitumor activity in MCF7 xenograft mice[1].
Product Specifications
CAS Number
[3008290-92-1]
UNSPSC
12352005
Target
Apoptosis; PI3K
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xjtu-l453.html
Smiles
NC([C@@H](OC1=CC(OCC2=C3C=C(C4=NC=NC(NCC)=C4)C=C2)=C3C=C1)C)=O
Molecular Formula
C22H22N4O3
Molecular Weight
390.44
References & Citations
[1]Shi X, et al. Rational Design of a Novel 6H-Benzo[c]chromen Series as Selective PI3Kα Inhibitors. J Med Chem. 2024 Aug 19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα
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