Ethoxzolamide
Ethoxzolamide is a carbonic anhydrase inhibitor with Ki of 1 nM.
Product Specifications
CAS Number
452-35-7
Product Name Alternative
Redupresin; L-643786; PNU-4191
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Bacterial; Carbonic Anhydrase
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Ethoxzolamide.html
Purity
99.85
Solubility
DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL
Smiles
O=S(C1=NC2=CC=C(OCC)C=C2S1)(N)=O
Molecular Formula
C9H10N2O3S2
Molecular Weight
258.32
Precautions
H315, H319, H335
References & Citations
[1]Maren TH, et al. Relations among IOP reduction, ocular disposition and pharmacology of the carbonic anhydrase inhibitor ethoxzolamide. Exp Eye Res. 1992 Jul;55 (1) :73-9.|[2]Benjamin K. Johnson, et al. The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits theMycobacterium tuberculosis PhoPR Regulon and Esx-1 Secretion and Attenuates Virulence. Antimicrob Agents Chemother. 2015 Aug; 59 (8) : 4436–4445.|[3]Song Gao, et al. Development and validation of an UPLC-MS/MS method for the quantification of ethoxzolamide in plasma and bioequivalent buffers: Applications to absorption, brain distribution, and pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Apr 1; 0: 54–59.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
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